Serine decomposition in solid-state catalytic isotope exchange of a peptide
✍ Scribed by Marika Eller; Dmitry Zaitsev; Bengt Fransson; Jaak Järv; Nikolai F. Myasoedov; Ulf Ragnarsson
- Book ID
- 103479333
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 362 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0045-2068
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## Abstract Solid state catalytic hydrogen isotope exchange has been employed to label hen egg lysozyme with tritium. Optimization of reaction conditions so that amino acids and peptide bonds remained intact led to a tritiated product with 97% of the original enzymatic activity and 94% radiochemica
## Abstract The results of the synthesis of 11 different tritiated alkylxanthines by solid‐phase catalytic isotope exchange are described. ^3^H‐NMR analysis of the labelled compounds shows that in contrast to liquid‐phase isotope exchange the tritium label is incorporated not only in the C‐8 (H) po