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Serial Cyclization of an Arachidonic Acid Hydroperoxide

✍ Scribed by Dr. Jamil A. Khan; Dr. Ned A. Porter

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
217 KB
Volume
21
Category
Article
ISSN
0044-8249

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## Abstract Incubation of murine spleen cells with the oxidation product of soybean lipoxidase‐treated arachidonic acid results in profound inhibition of induction of proliferation and maturation of these cells. The active entity was shown to be the 15‐hydroperoxide of arachidonic acid (15‐HPAA). I

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For the quantification of lipid hydroperoxides by high performance liquid chromatography (HPLC), it has been necessary to improve the detection system specific to the hydroperoxy group. We first developed a technique which combined detection by uv absorption due to conjugated diene and detection bas