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Sequential Sonogashira/Carbopalladative Cyclization/Suzuki Reactions Catalyzed by a Single Palladium Source by Using Protected Homopropargyl Alcohol

✍ Scribed by Xin Wang; Lingyan Liu; Weixing Chang; Jing Li

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 157 KB
Volume: 2010
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.201000515

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✦ Synopsis

Abstract

A novel cascade combination reaction catalyzed by a single palladium source for the synthesis of various indene derivatives is reported. The approach involved sequential Sonogashira/carbopalladative cyclization/Suzuki coupling reactions by using three readily available components, such as homopropargyl alcohol, aryl iodides or aryl bromides, and arylboronic acids. The overall domino reaction yields were up to 70 %.

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ChemInform Abstract: Sequential Sonogash

ChemInform Abstract: Sequential Sonogashira/Carbopalladative Cyclization/Suzuki Reactions Catalyzed by a Single Palladium Source by Using Protected Homopropargyl Alcohol.

✍ Xin Wang; Lingyan Liu; Weixing Chang; Jing Li 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 41 KB 👁 1 views

## Abstract Protected homopropargyl alcohol (I) is converted into indene derivatives by a new cascade sequence including Sonogashira coupling with aryl iodides (II) or aryl bromides (V), carbopalladative cyclization and Suzuki coupling with aryl boronic acids (III).