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Sequential Reductive Amination-Hydrogenolysis: A One-Pot Synthesis of Challenging Chiral Primary Amines

✍ Scribed by Thomas C. Nugent; Daniela E. Negru; Mohamed El-Shazly; Dan Hu; Abdul Sadiq; Ahtaram Bibi; M. Naveed Umar

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
245 KB
Volume
353
Category
Article
ISSN
1615-4150

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ChemInform Abstract: Sequential Reductiv
ChemInform Abstract: Sequential Reductive Aminationβ€”Hydrogenolysis: A One-Pot Synthesis of Challenging Chiral Primary Amines.
✍ Thomas C. Nugent; Daniela E. Negru; Mohamed El-Shazly; Dan Hu; Abdul Sadiq; Ahta πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons βš– 65 KB πŸ‘ 2 views

## Abstract A chromatography‐free synthesis of chiral primary amines via a one‐pot reaction (imine formation, imine reduction, and hydrogenolysis of the auxiliary) is presented.