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ChemInform Abstract: Sequential Reductive Amination—Hydrogenolysis: A One-Pot Synthesis of Challenging Chiral Primary Amines.

✍ Scribed by Thomas C. Nugent; Daniela E. Negru; Mohamed El-Shazly; Dan Hu; Abdul Sadiq; Ahtaram Bibi; M. Naveed Umar

Publisher: John Wiley and Sons
Year: 2011
Weight: 65 KB
Volume: 43
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201203050

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✦ Synopsis

Abstract

A chromatography‐free synthesis of chiral primary amines via a one‐pot reaction (imine formation, imine reduction, and hydrogenolysis of the auxiliary) is presented.

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