Sequential accumulation of the mutations in core promoter of hepatitis B virus is associated with the development of hepatocellular carcinoma in Qidong, China
β Scribed by Xia Guo; Yan Jin; Gengsun Qian; Hong Tu
- Book ID
- 116651666
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 221 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0168-8278
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## Abstract This study aimed to determine hepatitis B virus (HBV) mutations associated independently with the risk of hepatocellular carcinoma (HCC), as adjusted with other mutations in the preS and core promoter regions of HBV genotypes B and C. One hundred and forty HBVβinfected patients with HCC
The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region wer