Sequencing and Characterization of the Human Thiazide-Sensitive Na-Cl Cotransporter (SLC12A3) Gene Promoter
β Scribed by Steven MacKenzie; Henrikas Vaitkevicius; Warren Lockette
- Book ID
- 115587751
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 394 KB
- Volume
- 282
- Category
- Article
- ISSN
- 0006-291X
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Gitelman syndrome (GS) is characterized by salt-losing hypotension, hypomagnesemia, hypokalemic metabolic alkalosis, and hypocalciuria. To better model human GS caused by a specific mutation in the thiazidesensitive Na 1 -Cl Γ cotransporter (NCC) gene SLC12A3, we generated a nonsense Ncc Ser707X kno
## Abstract CationβCl^β^ cotransporters (CCCs) belong to a large family of proteins that includes 9 isoforms, two of which have still not been ascribed a transport function (CCC8 and CCC9) while the others are all known to promote Cl^β^βcoupled Na^+^ and/or K^+^ movement at the cell surface. The CC