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Molecular Cloning, Expression Pattern, and Chromosomal Localization of the Human Na–Cl Thiazide-Sensitive Cotransporter (SLC12A3)

✍ Scribed by Nadia Mastroianni; Maurizio De Fusco; Massimo Zollo; Giulia Arrigo; Orsetta Zuffardi; Alberto Bettinelli; Andrea Ballabio; Giorgio Casari

Book ID
115613342
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
843 KB
Volume
35
Category
Article
ISSN
0888-7543

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Generation and analysis of the thiazide-
Generation and analysis of the thiazide-sensitive Na+-Cl− cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome
✍ Sung-Sen Yang; Yi-Fen Lo; I-Shing Yu; Shu-Wha Lin; Tai-Hsiang Chang; Yu-Juei Hsu 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 660 KB

Gitelman syndrome (GS) is characterized by salt-losing hypotension, hypomagnesemia, hypokalemic metabolic alkalosis, and hypocalciuria. To better model human GS caused by a specific mutation in the thiazidesensitive Na 1 -Cl À cotransporter (NCC) gene SLC12A3, we generated a nonsense Ncc Ser707X kno