## Abstract Hepatitis C virus (HCV) infection may result in acute resolving or chronic infection. Patients that clear the infection have a more vigorous cellular immune response and an early humoral response to the hypervariable region 1 (HVR1) of the E2 envelope protein. To analyse further the pro
Sequences in the hypervariable region 1 of hepatitis C virus show only minimal variability in the presence of antibodies against hypervariable region 1 during acute infection in chimpanzees
β Scribed by Y.-H. Zhou; M. Sugitani; M. Esumi
- Publisher
- Springer Vienna
- Year
- 2002
- Tongue
- English
- Weight
- 96 KB
- Volume
- 147
- Category
- Article
- ISSN
- 1432-8798
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## Abstract Hepatitis C virus (HCV) infection is characterized by persistence of liver inflammation that often leads to endβstage liver disease, although the mechanisms are not fully understood. A hyperβvariable region (HVR) has been reported in the E2/NS1 region of the HCV genome, in which strikin
## Abstract A rare collection of serum samples from patients with hepatitis C virus (HCV) infection followed up from the onset of clinical symptoms was acquired. RNA corresponding to the hypervariable region 1 (HVR1) of E2 protein of HCV isolated from nine patients was reverseβtranscribed, amplifie
Hypervariable region I (HVRI) of the putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV) undergoes sequential alterations at intervals of several months during the chronic phase of hepatitis. To evaluate the implications of sequence variability in HVRl of HCV, we investigated the