Sequence variation in the proximity ofIDEmay impact age at onset of both Parkinson disease and Alzheimer disease
β Scribed by MiaE.-L. Blomqvist; PeterA. Silburn; DanielD. Buchanan; Niels Andreasen; Kaj Blennow; NancyL. Pedersen; AnthonyJ. Brookes; GeorgeD. Mellick; JonathanA. Prince
- Book ID
- 106257062
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 229 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1364-6745
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An increased frequency of the apolipoprotein E type 4 allele (APOE-4) has previously been associated with both late-onset sporadic and late-onset familial Alzheimer disease (AD) [
## Abstract Alzheimer's disease (AD) is a common neurodegenerative disorder of late life with a complex genetic basis. Although several genes are known to play a role in rare early onset AD, only the __APOE__ gene is known to have a high contribution to risk of the common lateβonset form of the dis