Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene
โ Scribed by Roberta A. Mittelstaedt; Beverly A. Smith; Tao Chen; Frederick A. Beland; Robert H. Heflich
- Book ID
- 114072647
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 77 KB
- Volume
- 431
- Category
- Article
- ISSN
- 0027-5107
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In a previous study, we found that treating transgenic Big Blue rats with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) produced the same major DNA adduct in the target liver and the nontarget spleen lymphocytes and bone marrow cells, induced lacI mutants in the liver, and induced
Treatment of female SpragueDawley rats with the potent mammary gland carcinogen 7,12dimethyC benz[a]anthracene (DMBA) results in the formation of DNA adducts with dG and dA and in the induction of 6thioguanineresistant (TG') lymphocyte mutants. In this study, we have examined the types of mutations