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Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene

โœ Scribed by Roberta A. Mittelstaedt; Beverly A. Smith; Tao Chen; Frederick A. Beland; Robert H. Heflich


Book ID
114072647
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
77 KB
Volume
431
Category
Article
ISSN
0027-5107

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In a previous study, we found that treating transgenic Big Blue rats with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) produced the same major DNA adduct in the target liver and the nontarget spleen lymphocytes and bone marrow cells, induced lacI mutants in the liver, and induced

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