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Sequence-Specific Targeting of RNA with an Oligonucleotide−Neomycin Conjugate

✍ Scribed by Charles, Irudayasamy; Xi, Hongjuan; Arya, Dev P.

Book ID
121404485
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
320 KB
Volume
18
Category
Article
ISSN
1043-1802

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## Background: A general method allowing the selective destruction of targeted mrna molecules in vivo would have broad application in biology and medicine. metal complexes are among the best synthetic catalysts for the cleavage of rna, and covalent attachment of suitable metal complexes to oligonuc