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Sequence-specific chemical modification of a 365-nucleotide-long DNA fragment with an alkylating oligonucleotide derivative

โœ Scribed by V.V. Vlassov; S.A. Gaidamakov; V.V. Gorn; S.A. Grachev


Book ID
115916743
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
337 KB
Volume
182
Category
Article
ISSN
0014-5793

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Sequence-specific chemical modification
โœ V. V. Vlassov; N. D. Kobetz; E. L. Chernolovskaya; S. G. Demidova; R. G. Borisso ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Springer ๐ŸŒ English โš– 301 KB

Chemical modification of the chromatin DNA with alkylating derivatives of oligothymidylate (pT)16 and oligoadenylate (pA)16 bearing 4-(N-2-chloroethyl-N-methylamino)benzylphosphamide group at the 5'-phosphate has been investigated. It was found that the derivatives do react with DNA in chromatin. Th