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Sequence-specific spin labeling of DNA

✍ Scribed by Ivana Weygand-Durasevic; Slavoljub Susic

Book ID
119119830
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
1002 KB
Volume
1048
Category
Article
ISSN
0167-4781

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## Abstract A new concept for sequence‐specific labeling of DNA by using chemically modified cofactors for DNA methyltransferases is presented. Replacement of the amino acid side chain of the natural cofactor __S__‐adenosyl‐L‐methionine with an aziridine group leads to a cofactor suitable for DNA m