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Sequence Selective Cleavage of a DNA Octanucleotide by Chlorinated Bithiazoles and Bleomycins

✍ Scribed by Zuber, Guy; Quada, James C.; Hecht, Sidney M.


Book ID
126930906
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
59 KB
Volume
120
Category
Article
ISSN
0002-7863

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An indolocarbazole compound, NB-506, inhibits the activity of topoisomerase I by stabilizing the DNA-topoisomerase I complex (cleavable complex). NB-506 inhibited the religation step of topoisomerase I activity more potently than camptothecin or its derivative, topotecan. A cleavage assay using an e