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Sequence-Selective and Hydrolytic Cleavage of DNA by Zinc Finger Mutants

✍ Scribed by Nomura, Akiko; Sugiura, Yukio


Book ID
115523873
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
73 KB
Volume
126
Category
Article
ISSN
0002-7863

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An indolocarbazole compound, NB-506, inhibits the activity of topoisomerase I by stabilizing the DNA-topoisomerase I complex (cleavable complex). NB-506 inhibited the religation step of topoisomerase I activity more potently than camptothecin or its derivative, topotecan. A cleavage assay using an e