Three genes encoding members of the M(r) 70,000 heat shock protein family (HSP70) are known to lie in the class III region of the human major histocompatibility complex. In order to determine whether these genes or their protein products exhibit any polymorphism the three genes have been specificall
Sequence Polymorphism and Evolution of Three Cetacean MHC Genes
โ Scribed by Shi Xia Xu; Wen Hua Ren; Shu Zhen Li; Fu Wen Wei; Kai Ya Zhou; Guang Yang
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 631 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-2844
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The nucleotide sequences of one Ovar-DQB gene, excluding exon 1 and parts of the introns, and one Ovar-DRB pseudogene are presented. The structure of the Ovar-DQB gene is typical of a major histocompatibility complex (MHC) class II B gene and demonstrates considerable sequence similarity with that o
A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene. Nucleotide sequence analysis of the two intronless genes, HSP70-1 and HSP70-2, has shown that they encode an id