Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes
✍ Scribed by Michel JAQUINOD; Noelle POTIER; Klaus KLARSKOV; Jean-Marc REYMANN; Odile SOROKINE; Sylvie KIEFFER; Patrick BARTH; Verotiana ANDRIANTOMANGA; Jean-François BIELLMANN; Alain VAN DORSSELAER
- Book ID
- 115130413
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 892 KB
- Volume
- 218
- Category
- Article
- ISSN
- 1432-1327
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A series of supramolecular complexes of various cycludextrins (CDs) was studied. Among the 13 CD complexes synthesized, 11 could be characterizied by electrospray ionization mass spectrometry. Different supramolecular entities, with host: guest ratios of 1 : 1 and 2: 1, were observed.
## Abstract Review: 108 refs.
The detection of non-covalent complexes in the mass range 19 000-34 000 Da, using electrospray ionization mass spectrometry (ESI-MS), is reviewed. The examples discussed include (1) a protein-ligand interaction (ras-GDP), (2) an inhibitor-protein-ligand interaction (SCH 54292/SCH 54341-ras-GDP), (3)