Sequence Kernel Association Test for Quantitative Traits in Family Samples
✍ Scribed by Chen, Han; Meigs, James B.; Dupuis, Josée
- Book ID
- 118758941
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 855 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0741-0395
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## Abstract Association mapping based on family studies can identify genes that influence complex human traits while providing protection against population stratification. Because no gene is likely to have a very large effect on a complex trait, most family studies have limited power. Among the co
In genetic analysis it is often of interest to analyze associations between traits of unknown genetic etiology and genetic markers from pedigree data. Statistical methods that assume independence of pedigree members cannot be used because they disregard the statistical dependencies of members in a p