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Sequence determinants of protein aggregation in human VH domains

✍ Scribed by Dudgeon, Kip (author);Famm, Kristoffer (author);Christ, Daniel (author)

Book ID
118043984
Publisher
Oxford University Press
Year
2008
Tongue
English
Weight
204 KB
Volume
22
Category
Article
ISSN
1741-0126

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Antibody heavy chain variable domains (VH) lacking their light chain (VL) partner are prime candidates for the design of minimum-size immunoreagents. To obtain structural information about isolated VH domains, a human VH was labelled with 15N or doubly labelled with both 15N and 13C and was studied