Nine bovine T-cell receptor (Tcr) gamma chain (Tcrg) and three Tcr delta chain (Tcrd) cDNA clones were isolated from the cDNA libraries constructed from peripheral blood lymphocytes and thymocytes. Of nine Tcrg cDNA clones, only four were rearranged and contained specific V, J, and C gene segments,
Sequence and organization of the human T cell δ chain gene
✍ Scribed by Yoshihiro Takihar; Eric Champagne; Henrik Griesse; Nobuhiro Kimura; Douglas Tkachuk; Jörg Reiman; Ami Okad; Frederick W. Alt; Leonard Ches; Mark Minden; Tak W. Mak
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 703 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0014-2980
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The T-cell receptor (Tcr) provides specificity for antigen recognition by its variable domain, primarily consisting of two germline encoded variable (I0 region gene segments. Thus it has been suggested that inherited polymorphisms in the TCRV gene segments could contribute to differential immune res
The nucleotide sequences of 38 T-cell receptor (Tcr) beta-chain cDNA clones which were isolated from a cDNA library (2 x 10(6) plaques) constructed from bovine peripheral blood lymphocytes were determined. Of 38 cDNA clones, 22 were rearranged and contained the functional variable (V) gene segments.