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Sequence and diversity of rat T-cell receptor α-chain-encoding genes

✍ Scribed by Carine Tischmann; Ulrich Feige; Doris Rüegg; Jill Gasser; Gerd Pluschke

Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
452 KB
Volume
39
Category
Article
ISSN
0093-7711

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✦ Synopsis

The o~/13 T-cell antigen receptor is formed by the combination of the o~ and 13 polypeptide chains which both consist of a constant and a variable portion. The genetic information for the variable portion on each chain is generated by rearrangements of variable (Tcr-V), diversity (Tcr-D, only for 13 chains), and joining (TCR-J) gene segments.The variable gene segments together determine the antigen specificity of a T cell. Characterization of the structure of the mouse and human Tcr gene segments, therefore, has expanded our understanding of T-cell repertoire selection and has helped to clarify the role of T cells in immune protection and T-cell-dependent pathologic processes. Although many rat major histocompatibility complex haplotypes are well defined and the rat is used as a model for a variety of inflammatory, infectious, and autoimmune diseases (Gill et al. 1989), only partial information is available about the structure and repertoire of rat Tcr genes (

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