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Sequence Analysis ofCandida albicans Phosphoribosyl-aminoimidazole Carboxylase (ADE2) Gene

✍ Scribed by Tsang, Wai-Kei Paul; Cao, Bo-Yang; Wang, Jun

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 269 KB
Volume: 13
Category: Article
ISSN: 0749-503X
DOI: 10.1002/(sici)1097-0061(19970615)13:7<673::aid-yea122>3.0.co;2-g

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✦ Synopsis

The nucleotide sequence of the Candida albicans ADE2 gene, which encodes phosphoribosylaminoimidazole carboxylase, has been determined. The sequence possesses an uninterrupted open reading frame of 1704 nucleotides corresponding to 568 amino acid residues. The deduced amino acid sequence shares a high degree of homology with ADE2 homologues in other fungal species including Saccharomyces cerevisiae, Pichia methanolica, Schwanniomyces occidentalis and Schizosaccharomyces pombe. Three regions of amino acid sequence were highly conserved among all reported ADE2 genes. The hexanucleotide TGACTC characteristic of genes involved in purine and amino acid biosynthesis is located in front of putative TATA boxes in the promoter region.

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