Virtually all of our present understanding of repertoire development in c~/3 T-cells, particularly at the molecular level, has come from studies on humans and mice but there has been very little work done on other species (reviewed by Davis and Bjorkman 1988;Strominger 1989). In some instances, the
Sequence analysis of DA and Sprague Dawley rat T-cell receptor β-chain promoters
✍ Scribed by James E. Sillibourne; R. A. Kay
- Book ID
- 105948642
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 345 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0093-7711
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The nucleotide sequences of 38 T-cell receptor (Tcr) beta-chain cDNA clones which were isolated from a cDNA library (2 x 10(6) plaques) constructed from bovine peripheral blood lymphocytes were determined. Of 38 cDNA clones, 22 were rearranged and contained the functional variable (V) gene segments.
The o~/13 T-cell antigen receptor is formed by the combination of the o~ and 13 polypeptide chains which both consist of a constant and a variable portion. The genetic information for the variable portion on each chain is generated by rearrangements of variable (Tcr-V), diversity (Tcr-D, only for 13