Sepsis: Current Perspectives in Pathophysiology and Therapy

✍ Scribed by J.-L. Vincent (auth.), Prof. Dr. Konrad Reinhart, Prof. Dr. Klaus Eyrich, Prof. Dr. Charles Sprung (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 1994
Tongue: English
Leaves: 572
Series: Update in Intensive Care and Emergency Medicine 18
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

The comprehensive coverage of the incidence, etiology, pathophysiology, definition, and therapy of sepsis and septic shock gives you the knowledge you need to keep up with modern therapeutic strategies.
The authors are either basic scientists or clinical researchers whose goal is to present the newest aspects of their work in comprehensible language. They clearly show the new perspectives that are emerging in the treatment of sepsis and septic shock.

✦ Table of Contents

Front Matter....Pages I-XVI
Front Matter....Pages 1-1
Sepsis and Septic Shock: Update on Definitions....Pages 3-15
Clinical Manifestations and Prognostic Indicators in Sepsis....Pages 16-22
What Determines Prognosis in Sepsis? Evidence for a Comprehensive Individual Patient Risk Assessment Approach to the Design and Analysis of Clinical Trials....Pages 23-37
A Scoring System for Multiple Organ Dysfunction Syndrome....Pages 38-49
Front Matter....Pages 51-51
Endotoxemia and Sepsis: Important Roles for Lipopolysaccharide Binding Protein and CD14 in Endotoxin Signal Transduction....Pages 53-60
Bacterial Exotoxins and Sepsis....Pages 61-85
Bacterial Translocation: Myth versus Reality....Pages 86-106
Tumor Necrosis Factor and Other Cytokines in Septic Syndrome....Pages 107-121
Role of Oxygen Free Radicals in the Pathophysiology of Sepsis....Pages 122-135
Front Matter....Pages 137-137
Cardiocirculation in Sepsis....Pages 139-149
A Current View of Oxygen Supply Dependency....Pages 150-162
Sepsis and Nutritional Blood Flow....Pages 163-173
Endothelial Cell Function in the Critically Ill....Pages 174-180
Sepsis and Cellular Metabolism....Pages 181-190
Front Matter....Pages 191-191
Monitoring of O 2 Transport and Tissue Oxygenation in Septic Shock....Pages 193-213
Front Matter....Pages 215-215
Sepsis-Related Problems in Pediatric Patients....Pages 217-227
Definitions and Therapy of Sepsis....Pages 228-238
Role of Surgical Intervention in the Prevention and Therapy of Sepsis....Pages 239-245
Antibacterial Treatment of Sepsis....Pages 246-255
Diagnostic and Therapeutic Approach in Invasive Fungal Infections of Intensive Care Unit Patients....Pages 256-265
Front Matter....Pages 215-215
Fluid Therapy in Sepsis....Pages 266-273
Influence of Catecholamines on Regional Perfusion and Tissue Oxygenation in Septic Shock Patients....Pages 274-291
Metabolic Changes in Sepsis — Can the Host Response be Influenced Metabolically?....Pages 292-304
Front Matter....Pages 305-305
Is there a Place for Monoclonal Antibodies Against Endotoxin in the Therapy of Sepsis?....Pages 307-313
Endotoxin in Septic Shock....Pages 314-336
Tumour Necrosis Factor as a Therapeutic Target in Sepsis....Pages 337-348
Tumor Necrosis Factor-Neutralization with a Specific Monoclonal Antibody....Pages 349-356
Cardiovascular Effects of Repeated Administration of the F(ab′) 2 Fragment of an Anti-tumor Necrosis Factor-α Monoclonal Antibody in Patients with Severe Sepsis....Pages 357-370
Modulating Effects of Pentoxifylline on Cytokine Release Syndromes....Pages 371-381
The Treatment of Sepsis with Interleukin-1 Receptor Antagonist....Pages 382-390
The Function and Potential Therapeutic Value of Lipopolysaccharide Binding Protein During Gram-Negative Sepsis: Recombinant Expression and Promoter Studies....Pages 391-396
Platelet-Activating Factor: Pathophysiological Changes and Therapeutic Implications in Sepsis....Pages 397-413
Potential of Oxyradical Scavengers in the Therapy of Sepsis....Pages 414-424
N-Acetylcysteine in Sepsis....Pages 425-442
Immunoaugmentation: A Contribution to Prophylaxis and Treatment of Sepsis?....Pages 443-448
What Is Certain in the Treatment with Immunoglobulins?....Pages 449-463
Arachidonic Acid Metabolism in Sepsis: What is the Role of Cyclooxygenase Inhibition?....Pages 464-472
Improvement of Monocyte Function — A New Therapeutic Approach?....Pages 473-500
From Localized Angioedema to Generalized Capillary Leak Syndrome: Evidence for a Pivotal Role of C1-Inhibitor in Septic Shock-like Syndromes....Pages 501-527
Potential for Gene Therapy in the Treatment of Sepsis....Pages 528-535
Front Matter....Pages 537-537
Step-by-Step Treatment of Acute Respiratory Distress Syndrome....Pages 539-548
Perfluorocarbons as an Alternative Respiratory Medium....Pages 549-563
Back Matter....Pages 565-570

✦ Subjects

Intensive / Critical Care Medicine; Anesthesiology; Surgery; Internal Medicine; Pediatrics

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