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Sepsis and septic shock

✍ Scribed by Jiri Mayer; Roman Hajek; Jiri Vorlicek; Miroslav Tomiska

Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
574 KB
Volume
3
Category
Article
ISSN
0941-4355

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✦ Synopsis

Mortality from septic shock is considerable despite the advantages of cardiovascular support and antibiotic therapy. Understanding the pathophysiology of sepsis enables clinicians to institute rational intervention directed towards the pathophysiological mechanisms. This article reviews definitions of sepsis and offers a brief overview of ist pathophysiology. Current knowledge on the pa-thophysiological mechanism of cytokines and modulation of systemic cytokine levels during sepsis and septic shock is discussed. The important role of cytokines in sepsis and septic shock may require more detailed investigations of the cytokine pathophysiological network.

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## Abstract Sepsis causes significant alterations in the hepatic macro‐ and microcirculation. Diverging views exist on global hepatic blood flow during experimental sepsis because of the large variety in animal and sepsis models. Fluid‐resuscitated clinical sepsis is characterized by ongoing liver