## Abstract Sepsis causes significant alterations in the hepatic macroβ and microcirculation. Diverging views exist on global hepatic blood flow during experimental sepsis because of the large variety in animal and sepsis models. Fluidβresuscitated clinical sepsis is characterized by ongoing liver
Pharmacogenomics in sepsis and septic shock
β Scribed by David Shaw; James A. Russell; Keith R. Walley
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 133 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0272-4391
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π SIMILAR VOLUMES
Patients with cirrhosis are susceptible to bacterial infection, which can result in circulatory dysfunction, renal failure, hepatic encephalopathy, and a decreased survival rate. Severe sepsis is frequently associated with adrenal insufficiency, which may lead to hemodynamic instabity and a poor pro
## Abstract ## BACKGROUND: Hospitalized patients who develop severe sepsis have significant morbidity and mortality. Early goalβdirected therapy has been shown to decrease mortality in severe sepsis and septic shock, though a delay in recognizing impending sepsis often precludes this intervention.