Sepsis and Organ Dysfunction: The Challenge Continues

✍ Scribed by A. E. Baue (auth.), A. E. Baue M.D., G. Berlot M.D., A. Gullo M.D., J.-L. Vincent M.D. (eds.)

Publisher: Springer-Verlag Mailand
Year: 2000
Tongue: English
Leaves: 164
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

An experienced physician knows how to recognize a patient suffering from sepsis, but cannot accurately determine whether the patient will survive. Cardinal elements of the treatment for sepsis include specific antibiotic and vasoactive drugs, enteral and parenteral nutrition, artificial respiration, and optimization of the oxygen transport to tissues. Nonetheless, with a certain frequency, these techniques are insufficient to ensure the recovery of a critically ill patient, especially when it is necessary to overcome functional alterations subsequent to organ and vital-system overload. The key elements in the progression of the sepsis-MODS syndrome are tied to numerous factors. These include: the severity and location of the lesion; the patient's age; the remaining functional reserve; the presence of mediatory which may be stimulatory, inhibitory or both.

✦ Table of Contents

Front Matter....Pages I-IX
Introduction....Pages 11-15
Sepsis and Organ Dysfunction. The Challenge Continues....Pages 17-33
Front Matter....Pages 35-35
Biochemical Regulation of the Microcirculation....Pages 37-41
Oxygen Supply and Consumption in Tissues....Pages 43-48
Ischaemia-Reperfusion in Sepsis....Pages 49-56
Mechanism of Oxygen Extraction Defect in Septic Shock....Pages 57-63
Front Matter....Pages 65-65
Gut Perfusion in Sepsis and Shock....Pages 67-76
Pathophysiology of Encephalopathy....Pages 77-83
Lung Dysfunction in the Early Phase of Sepsis....Pages 85-90
The Kidney in Sepsis....Pages 91-101
Pathophysiology of Liver Dysfunction in Sepsis....Pages 103-106
Inflammatory Cells in Septic Shock....Pages 107-112
Front Matter....Pages 113-113
Revised Terminology on Sepsis....Pages 115-121
The Epidemiology and Outcome of Patients with Sepsis: Clear as Mud....Pages 123-135
Are There Useful New Markers of Sepsis?....Pages 137-143
A Paradigm Shift: The Bidirectional Effect of Inflammation on Bacterial Growth....Pages 145-154
Is the Dosing and Timing of the Intervention Adequate?....Pages 155-160
Clinical Trials of Mediator-Targeted Therapy in Sepsis....Pages 161-174
Back Matter....Pages 175-178

✦ Subjects

Intensive / Critical Care Medicine; Anesthesiology

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