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Separation of some chloramphenicol intermediates by high-pressure ion-exchange chromatography

✍ Scribed by Gy. Vigh; J. Inczédy

Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
185 KB
Volume
102
Category
Article
ISSN
1873-3778

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✦ Synopsis

High-pressure cation-exchange chromatography was used to separate three of the by-product compounds formed in the chloramphenicol production process. Baseline separation can be achieved within 8.5 min employing a l-m column packed with Zipax SCX pellicular cation exchanger and 0.05 M sodium sulphate solution as eluent at pH I,1 in a Varian Aerograph LC 4020 liquid chromatograph.

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