Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyproline
β Scribed by Karl Tryggvason; Juha Risteli; Kari I. Kivirikko
- Book ID
- 118311585
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 438 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0006-291X
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## Abstract The conformations of peptides and proteins are often influenced by glycans __O__βlinked to serine (Ser) or threonine (Thr). (2__S__,4__R__)β4βHydroxyproline (Hyp), together with Lβproline (Pro), are interesting targets for __O__βglycosylation because they have a unique influence on pept
Treatment of the 9-phenylflnoren-9-yl (Pt) protected 4-oxo-proline-ethyl ester (6) with NaI-IMDS and N-(5-chioro-2-pyridyi)triflimide gives the corresptmding enoitriflate in good yield. Pd ~ of the ~ with u'~,la~n~ .~ethyia~lt~ utmethy~U~enymn and carton monoxide proceeds to give the 4-substituted-3