A simple route to 4-substituted-3,4-didehydroprolines. Mechanistic probes for the inhibition of prolyl-4-hydroxylase

✍ Scribed by Ari M.P. Koskinen; Jörg Schwerdtfeger; Michael Edmonds

• Book ID: 104257537
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 176 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01182-9

✦ Synopsis

Treatment of the 9-phenylflnoren-9-yl (Pt) protected 4-oxo-proline-ethyl ester (6) with NaI-IMDS and N-(5-chioro-2-pyridyi)triflimide gives the corresptmding enoitriflate in good yield. Pd ~ of the ~ with u'~,la~n~ .~ethyia~lt~ utmethy~U~enymn and carton monoxide proceeds to give the 4-substituted-3,4-didehyd.-c, ga-olines.