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Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch

✍ Scribed by Christian Haass; Luka Kulic; Anja Capell; Harold Steiner; Gerd Multhaup; David Teplow; Helmut Romig

Book ID
117411583
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
177 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract It seems likely that the β‐amyloid precursor protein (APP) and the presenilins (PS‐1/2) play important roles in the development of Alzheimer's disease (AD). Attempts to mimic the biochemical actions of these proteins are often made by the application of fragments of these proteins. Howe