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Separation of penicillins of closely related structure by partition chromatography on paper and cellulose thin-layer plates

✍ Scribed by S.C. Pan

Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
428 KB
Volume
79
Category
Article
ISSN
1873-3778

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✦ Synopsis

By applying the technique of real partition chromatography

to systems in which aqueous buffer solutions are used as the stationary phase, natural or semisynthetic penicillins of closely related structure can be satisfactorily separated. Water-saturated alkanols of proper polarity and buffers of proper pH are chosen as the mobile and stationary phases, respectively, according to the polarity of the penicillin to be chromatographed.

Examples of penicillins separated are ampicillin vs. epicillin, their N-acetyl derivatives, penicillins G vs. penicillin V, ?IZ-vs. p-hydroxybenzylpenicillins and I~Z-vs. fi-hydroxyampicillins,

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