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Identification and separation of closely related sulfa drugs by thin-layer chromatography on cadmium acetate-impregnated silica gel plates

✍ Scribed by S.P. Sprivastava; V.K. Dua; R.N. Mehrotra; R.C. Saxena

Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
173 KB
Volume
176
Category
Article
ISSN
1873-3778

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✦ Synopsis

Recently the impregnation of thin-layer plates with different substances has been tried in order to improve the separation of various classes of substances. Yasudal-J reported the use of different metal salts for the separation of aromatic amines, while Srivastava and Dua, in this laboratory, have developed suitable impregnants for the separation of phenolss, aromatic amine@, aliphatic amines', diols8 and amino acids9 by thin-layer chromatography (TLC). The loading of papers with strong acid exchange resin has been employed by Pietrzyk and Chan-Santosr" for the separation of some sulfa drugs. However, no work seems to have been done, on the TLC separation of sulfa drugs on impregnated plates. The present paper reports our studies on the use of impregnated silica gel plates for the separation and identification of ten sulfa drugs.

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