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Separation of norepinephrine enantiomers, DOPA enantiomers and dopamine derivatized with o-phthalaldehyde-N-acetyl-l-cysteine by high-performance liquid chromatography

✍ Scribed by Noriyuki Nimura; Kazuo Iwaki; Toshio Kinoshita

Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
276 KB
Volume
402
Category
Article
ISSN
1873-3778

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Determination of eflornithine enantiomer
Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-l-cysteine and liquid chromatography with UV detection
✍ R. Jansson-Löfmark; S. Römsing; E. Albers; M. Ashton 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 1 views

## Abstract A bioanalytical method for indirect determination of eflornithine enantiomers in 75 μL human plasma has been developed and validated. l‐ and d‐eflornithine were derivatized with __o__‐phthalaldehyde and __N__‐acetyl‐L‐cysteine to generate diastereomers which were separated on two serial