Separation of enantiomers of drugs by capillary electrophoresis. Part 4: Hydroxyprpyl-gammacyclodextrin as chiral solvating agent

✍ Scribed by Priv.-Doz. Dr. Bernhard Koppenhoefer; Ulrich Epperlein; Zhu Xiaofeng; Lin Bingcheng

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 538 KB
• Volume: 18
• Category: Article
• ISSN: 0173-0835
• DOI: 10.1002/elps.1150180612

✦ Synopsis

Separation of enantiomers of drugs by capillary electrophoresis. Part 4 : Hydroxypropyl-gammacyclodextrin as chiral solvating agent

In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-y-cyclodextrin as chiral solvating agent (CSA). A total of 30 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a statistical treatment of the data. The enantioseparation of the analytes is correlated with their interaction strength with the CSA. Hence, the concentration of the CSA is a crucial parameter for optimization of the enantioseparation, as shown by a subset of 23 examples.