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Separation of enantiomers of 4-aryldihydropyrimidines by direct enantioselective HPLC. A critical comparison of chiral stationary phases

✍ Scribed by Oliver P. Kleidernigg; C.Oliver Kappe

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 696 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(97)00214-0

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✦ Synopsis

The separation of the enantiomers of 29 racemic 4-aryldihydropyrimidine-5carboxylates (DHPMs), aza-analogs of nifedipine-type dihydropyridine calcium channel modulators, was evaluated in direct enantioselective HPLC, employing the following commercially available chiral stationary phases (CSPs): Chiralcel OD-H, ChiraDex, Chirobiotic V and T, and Whelk-O1. In addition, a 1,2-diphenyl-l,2-diaminoethane based CSP and two quinine carbamate based chiral ion exchangers were also employed. For all 29 DHPMs separation of individual enantiomers could be achieved with at least one CSP with 0t-values ranging from 1.10 to 8.67. (~) 1997 Elsevier Science Ltd

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