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Separation of enantiomers by microcolumn liquid chromatography with methylated β-cyclodextrin as mobile phase additive

✍ Scribed by Rongzong Hu; Toyohide Takeuchi; Ji-Ye Jin; Tomoo Miwa

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
606 KB
Volume
295
Category
Article
ISSN
0003-2670

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✦ Synopsis

Enantiomers can be separated by microcolumn liquid chromatography with methylated &cyclodextrin @-CD) as a mobile phase additive. Effects of the mobile phase composition on the retention behaviour of the analytes were examined. The separation factor achieved with heptakis(2,3,6-tri-0-methyl)+-CD as the chiral selector for l,l'-binaphthyl-2,2'-diyl hydrogenphosphate enantiomers was up to 3. Heptakis(2,6-di-0-methyl&&CD achieved poor enantioselectivities for the enantiomers examined.

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