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Separation of [18F]fluoride from [18O]water using anion exchange resin

✍ Scribed by David J. Schlyer; Miguel A.V. Bastos; David Alexoff; Alfred P. Wolf

Publisher
Elsevier Science
Year
1990
Weight
280 KB
Volume
41
Category
Article
ISSN
0883-2889

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✦ Synopsis

The separation of no carrier added [18F]fluoride from 18O enriched water is described. The [18F]fluoride is deposited on Dowex 1 x 10 anion exchange resin as the water is passed through. The 18F is removed by elution with a dilute solution of cesium carbonate or potassium carbonate in water. Recovery of the 18F is greater than 95% efficient with a loss of 18O water of less than 5 microL from a volume of 3 mL.

πŸ“œ SIMILAR VOLUMES

Extraction of [18F]fluoride from [18O]wa
Extraction of [18F]fluoride from [18O]water by a fast fibrous anion exchange resin
✍ Douglas M. Jewett; Steven A. Toorongian; Michael A. Bachelor; Michael R. Kilbour πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science βš– 369 KB

[18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K2CO3. Extraction into methanol facilitated rapid evaporation and resolubilization of the [18F]fluoride

Aqueous carbonic acid: A readily removab
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✍ Douglas M. Jewett πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science βš– 257 KB

[18F]Fluoride was recovered from [18O]target water in high yield by trapping it on a microcolumn of an anion exchange resin (20 mg Dowex 1 x 8, 400 mesh) and subsequent elution of the column (in the reverse direction) by aqueous carbonic acid at 52 atm. The carbonic acid was removed from the [18F]fl