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Extraction of [18F]fluoride from [18O]water by a fast fibrous anion exchange resin

✍ Scribed by Douglas M. Jewett; Steven A. Toorongian; Michael A. Bachelor; Michael R. Kilbourn

Publisher: Elsevier Science
Year: 1990
Weight: 369 KB
Volume: 41
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(90)90044-h

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✦ Synopsis

[18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K2CO3. Extraction into methanol facilitated rapid evaporation and resolubilization of the [18F]fluoride as an ion pair. The resin was first dried in situ and rehydrated with [18O]H2O to avoid isotopic dilution of the target water.

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