Separation and quantification of the ethylfluoro and the dimethylfluoromethyl derivatives from their parent silicon compounds by gas chromatography

✍ Scribed by Soto-Garrido, G. ;Sherwood, A. G. ;Bell, T. N.

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 175 KB
• Volume: 12
• Category: Article
• ISSN: 0935-6304
• DOI: 10.1002/jhrc.1240120626

✦ Synopsis

MS using selected ion monitoring (SIM) for underivatized and 0-TMS derivatives. The selected ion for each compound is also presented A fragmentation pattern of the electron impact mass spectra is summarized in Table 3.

According to these results the following conclusions can be reached: a) High resolution gas chromatography is a suitable method for separation of mixtures of P-blocking drugs.

b) The mass spectra of each compound allows their unambiguous identification, despite the variety of the strutures studied. The general fragmentation pattern obtained could be used to identify unknown P-blockers.

c) The need for derivatizahon should be evaluated in each particular case according to the dose employed and plasma or urine levels reached for a given drug, taking into account that the limits of detection are between 10-60 hmes better for the derivatized drugs d) The information described is useful for pharmacokinehcs, drug abuse, and antidoping studies