Separation and identification of some hyrdoxychalcones and their derivatives

✍ Scribed by H.M. Chawla; S.S. Chibber; Ramesh Saigal

• Publisher: Elsevier Science
• Year: 1977
• Tongue: English
• Weight: 157 KB
• Volume: 138
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)98019-1

✦ Synopsis

Biogenetically, chalcones form an important class of organic natural products which are known to be precursors of various classes of flavonoids in plants'. In our investigations on the sensitized photooxygenations of chalcones with singlet oxygen2, it was observed that 2',4',6'-trihydroxychalcone could be converted into the corresponding flavonol, galangin. To study this chalcone-flavonol reaction from a mechanistic point of view, chalcones with different oxygenation patterns were synthesized and purified_ The known methods of purification by chromatography3 were found to be inadequate owing to the presence of unreacted materials, side reactions and polymerization during their synthesis. However, the application of our recent findings-on thin-layer chromatography with nitrobenzene-treated plates gave satisfactory results and a mixture of 18 chalcones could be resolved and detected on a single chromatogram. In this paper, we report the procedure for purification, separation and identification of various chalcones and their derivatives given in Table I.