β Scribed by T. A. Mastryukova
No coin nor oath required. For personal study only.
The addition of Schiff bases of a-aminoacid esters to vinylphosphoryl compounds was studied as a method for the synthesis of phosphinothricin and its analogues. The reaction was found to proceed smoothly in DMSO in the presence o f strong nitrogen bases and under the conditions of phase transfer catalysis. The Claisen condensation of P-phosphorylated propionitrile with diethyl oxalate was studied; phosphotylated derivatives of hydroxycitraconic acid nitrile were prepared on hydrolysis; transformation of such a derivative into a cyclic imide as well as into trimethylsilyl esters of these acids and their Z + E transformation were investigated. Cyclization reactions between a,w-dibromoalkanes and phosphoryl compounds containing an active methylene group affording cycbpropane and other cyclic derivatives were studied. The cyclopropane ring is cleaved by amines to give aminophosphinocarbox.ylic acids.
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