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Separate Processes Mediate Nucleotide-Induced Inhibition and Stimulation of the ATP-Regulated K+-channels in Mouse Pancreatic β -cells

✍ Scribed by Krister Bokvist, Carina Ammala, Frances M. Ashcroft, Per-Olof Berggren, Olof Larsson and Patrik Rorsman

Book ID
123660712
Publisher
The Royal Society
Year
1991
Tongue
English
Weight
828 KB
Volume
243
Category
Article
ISSN
0080-4649

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✍ William F. Hopkins; Sahba Fatherazi; Bettina Peter-Riesch; Barbara E. Corkey; Da 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 895 KB

ATP-inhibited potassium channels (K(ATP)) were studied in excised, inside-out patches from cultured adult mouse pancreatic beta-cells and HIT cells. In the absence of ATP, ADP opened K(ATP) channels at concentrations as low as 10 microM and as high as 500 microM, with maximal activation between 10 a