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Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease

✍ Scribed by Hongxing Wang; Jue He; Ruiguo Zhang; Shenghua Zhu; Junhui Wang; Lynda Kong; Qingrong Tan; Xin-Min Li


Book ID
116286849
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
637 KB
Volume
233
Category
Article
ISSN
0166-4328

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## Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with senile β‐amyloid (AΞ²) plaques and cognitive decline. Neurogenesis in the adult hippocampus is implicated in regulating learning and memory, and is increased in human postmortem brain of AD patients. Howe