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Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice

✍ Scribed by Frankland, P W; Wang, Y; Rosner, B; Shimizu, T; Balleine, B W; Dykens, E M; Ornitz, E M; Silva, A J


Book ID
110059724
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
141 KB
Volume
9
Category
Article
ISSN
1359-4184

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The fragile X mental retardation 1 gene (FMR1) mutation is strongly correlated with specific and marked neurobehavioral and neuroanatomical abnormalities. The protein product, FMRP, is highly expressed in neurons of the normal mammalian brain, and absent or in low levels in leukocytes from individua