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Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate

✍ Scribed by Lawrence Panasci; Bertrand J. Jean-Claude; Daniela Vosilescu; Amir Mustafa; Sorin Damian; Zoe Damian; Elias Georges; Zhi Liu; Gerald Batist; Brian Leyland-Jones


Book ID
115784682
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
848 KB
Volume
52
Category
Article
ISSN
0006-2952

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## Abstract The pure steroidal anti‐estrogens ICI 164,384 and ICI 182,780 are very potent growth inhibitors of the estrogen receptor‐positive human breast cancer cell line MCF‐7. However, long‐term treatment of MCF‐7 cells with 10^βˆ’7^ M concentrations of these compounds results in selection of prol