In this study the ability of the new pure anti-estrogen IcI 182,780 to modulate the cytotoxic action of adriamycin (ADR) on parental and ADR-resistant MCF-7 (MCF-7 ADRr) human breast-cancer cells was investigated and compared with that of tamoxifen (TAM). TAM enhanced ADR cytotoxicity in MCF-7 ADRr
Duration of remission to ICI 182,780 compared to megestrol acetate in tamoxifen resistant breast cancer
โ Scribed by J.F.R. Robertson; A. Howell; D.J. De Friend; R.W. Blarney; P. Walton
- Book ID
- 114316998
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 393 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-9776
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The effects of the anti-estrogens 4-hydroxytamoxifen (OHTam), ICI 164,384 and ICI 182,780 were tested on the MCF-7/LCC2 breast-carcinoma cell line, which grows significantly in the presence of OHTam and serves as a model for studying anti-estrogen resistance of estrogen-receptor-positive breast canc
## Abstract Inhibiting estrogen receptor (ER) function with specific estrogen receptor modulators (SERM) can achieve a primary response in cancer patients; however, intrinsic or subsequently acquired resistance to the therapy remains a major obstacle in treatment. The pure antiโestrogen fulvestrant