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Sensitization of hyperthermic treatment of leukemic cell lines by a synthetic peptide

✍ Scribed by Yasuharu Hori; Rie Nagai; Naomi Urabe; Toshikazu Yoshikawa; Masami Otsuka

Book ID
108479117
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
269 KB
Volume
10
Category
Article
ISSN
0968-0896

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## Abstract L1AD3 is a small cyclic synthetic peptide designed to resemble the first loop of a cobra venom cytotoxin. Instead of inducing membrane disruption similar to that caused by the parent toxin, L1AD3 promotes extensive and unusually rapid apoptosis in leukemic T‐cells without making the pla