A Cyclic Peptide (L1AD3) Induces Early Signs of Apoptosis in Human Leukemic T-Cell Lines

A cyclic peptide, L1AD3, induces early s

A cyclic peptide, L1AD3, induces early signs of apoptosis in human leukemic T-cell lines

✍ Charles A. Smith; Channing L. Hinman 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 278 KB

## Abstract L1AD3 is a small cyclic synthetic peptide designed to resemble the first loop of a cobra venom cytotoxin. Instead of inducing membrane disruption similar to that caused by the parent toxin, L1AD3 promotes extensive and unusually rapid apoptosis in leukemic T‐cells without making the pla